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Funded Projects

Rapid effects assessment of explosives using genomics and quantitative markers of exposure
  1. Developed, and implemented gene arrays permitting rapid assessment of 24DNT and RDX toxicity mechanisms in fathead minnow.
Rapid assays for munitions-related compound effects
  1. Developed rapid assays to assess whole genome impacts of munition-related compounds: Gene arrays, short exposure screening in Daphnia, rat cells, rat livers, and fish.
  2. Dramatically accelerated time to assess sublethal effects and mode of action.
Quantitative markers of munitions-related compound exposure
  1. Genetic markers of exposure in rat, earthworms, Daphnia magna and fish.
Molecular mechanisms of munitions-related compound toxicity
  1. Bobwhite Quail: RDX, 26DNT.
  2. Earthworms: TNT, RDX, Lead.
  3. Rats: RDX, TNT, 26DNT, 24DNT, 4ADNT, 2ADNT, Tungsten and tungstate toxicity.
  4. Fathead minnow: 24DNT, RDX.
Classification of munitions-related compound exposure by genomics
  1. Developed gene markers for earthworms, rat cell cultures, and fish that permit discriminating chemicals by effects on gene expression.
Conservation of munitions-related compound responses across species
  1. Meta analysis of RDX impacts on rat, fathead minnows, earthworms, Northern Bobwhite quail, water fleas ( Daphnia magna), coral (Acropora formosa).
  2. Comparison of genomic and behavioral responses of fathead minnow and zebrafish to RDX exposure.
  3. Conservation of response to nitroaromatics across species.
Toxicogenomic assessment framework for integration into predictive toxicology of munitions-related compounds
  1. Toxicogenomics in Ecological Risk Assessment. Taylor and Francis, SETAC Press.
  2. Tools, protocols and information databases permitting rapid assessment of munitions-related compound impacts on aquatic species (fathead minnow, Daphnia magna), Terrestrial species (rat, earthworm), and avian species (Bobwhite quail).
Field Application of Genomic Tools
  1. Screening soil for explosives contamination and bioavailability using earthworm gene assays.
Environmental Laboratory